Abstract: Data security protection is the integrity, availability and confidentiality protection of the important data. And data integrity protection is the key part of the three targets. The data integrity protection based on block chain technology is to protect the security of the data assets by signing and validating the data assets from the integrity of the data assets. The signature data is saved in the block chain storage by using the non-tampering and non-repudiation characteristics of block chain technology. It ensures the integrity and authenticity of the signature data safely and effectively. Through this research, the digital signature technology of "active integrity protection" is used to protect the large quantity of data assets, and the system provides high availability and extensibility design, which ensures that the total time cost of digital signature and data verification under the scale of application is approximately seconds level.