Abstract: Based on discrepancy analysis of command activities between combat platforms and military systems of systems (MSoS) in physical, cyber, and cognitive domains, the PREA Loop for the general MSoS process is proposed: Planning-Readiness-Execution-Assessment-Planning. From the perspective of the PREA loop, mechanism evolution of command confrontation for MSoS is analyzed and a mechanism leading to wins is presented: decision over action, stability over speed, and focus on result-oriented accumulation of effective and e±cient elements. In the light of the PREA-based command and control mechanism, the MSoS strategies can be induced to disturb opponents' PREA loops and protect alliances' PREA loops. To disturb opponents' PREA loop, the best way is to attack their strategies, the second best way is to interrupt their deployments, and the last and unwise decision is to confront directly. To protect alliances' PREA loops, the best way is to emphasize planning, the second best way is to emphasize PREA loop's stability, and the third best way is to emphasize on results of actions and especially the accumulation of elements and factors leading to higher e®ective and e±cient decisions and actions.