Abstract: Based on incomplete information game theory, a target optimization model for multi-shot missile launching path planning is established. In this model, the attack-defense game of road network nodes, overall exposure time, maximum exposure time of single vehicle and decentralized maneuver of the route are considered comprehensively. Through Floyd shortest path algorithm and heuristic search strategy, the model is verified and solved. The research results have a strong reference significance for missile launching path planning in practice.