Abstract: In order to analyze and draw lessons from the relevant theories of American mosaic warfare, this its important concepts are studied and sorted out. Based on the analysis of typical manned and unmanned swarm control structure, combined with the concept of mosaic warfare, a new underwater manned and unmanned swarm control structure utilizing swarm center replacement mechanism is proposed. The structure fully considers the environmental constraints of underwater space operations, and has the characteristics of simplified command level, swarm autonomy, flexibility and practicability. The simulation results show the effectiveness of the structure.