Abstract: To solve the problem of air defense deployment with multiple weapons, the military perspective of operations research is adopted, and it is proposed to transform the fixed-point air defense in the main place into the regional air defense in the main place, and take the deployment of troops in the air defense area as the research object. A mathematical model of regional air defense deployment optimization is proposed, and a genetic algorithm for solving the model is designed. A multi-weapon and multi-defense anti-aircraft deployment application example is used for verification, and a good optimization effect is achieved.