Abstract: This paper carries out research on the system and technical issues of command and control (C2) in manned/unmanned aerial vehicle (MAV/UAV) cooperative operation. It summarizes the test situation of MAV/UAV cooperative operation verification project, and then analyzes the composition of the cooperative operation system, C2 structure and C2 complexity. Combined with combat characteristics and mission requirements, a hierarchical C2 system structure including a computing communication layer, a coordinated control layer, and a planning and decision-making layer is proposed. Based on the di erence in decision-making granularity, three decision-making levels of group, formation and single drone are divided, the key technologies in the decision-making module, such as decision-making mode selection and transition, auxiliary decision-making and human-machine coordination, are analyzed, and finally, the future research directions are prospected.