Abstract: In view of the complexity， heterogeneity and other practical problems of multi-agent systems mechanism modeling in the field of intelligent manufacturing, an integrated architecture design method for multi-agent systems combined with industrial internet and cloud control is proposed. The analytic problem of heterogeneous system communication protocol and the consistency problem of computing environment in cloud network edge are solved. The information flow between heterogeneous agents is unlocked, reducing the development cost and improving the reuse rate of technical resources are achieved. Finally, the feasibility of the proposed architecture is verified by an unmanned factory composed of a set of highly automated equipment.