Abstract: With the development of intelligent attacks, attacks trend to collude to improve the stealthiness and to cause more damages, which brings great challenges for multi -agent systems to execute coordinated control tasks under complex environment. Under the constrained ability of attack collusion, the distributed isolation algorithm against collusive attacks is designed, and a sufficient condition is analyzed to accomplish zero missed attack alarm. Base on this, the resilient control algorithm based on attack isolation is proposed to assure the accomplishment of assigned consensus task by normal agents and to improve the resilience and invulnerability of multi-agent systems.