Abstract: Time and space are the basis of all activities for human survival and development. Spatiotemporal big data is big data related to geographical location with both time and space dimensions, and it is an important support for emergency command and control of public health events. Aiming at the various problems that emerged in the emergency response of the new coronary pneumonia epidemic in China, the application of spatiotemporal big data in the emergency response of the new coronary pneumonia epidemic is summarized. On this basis, the problems existing in the emergency command system of emergent public health events in China and the challenges faced by spatiotemporal big data in emergency command of emergent public health events are analyzed. Finally, a spatiotemporal big data emergency command technology framework for emergent public health events is proposed, in order to deepen the application of spatiotemporal big data in the field of emergent public health events.