Abstract: Supporting the agile construction of kill chain is a core capability of network information systems. To quantify this capability, a hierarchical model of architecture of network information system is established based on three elements of tasks, nodes and association. Then, on that basis, the measurement methods of complexity, adaptability, robustness and efficiency of the architecture are designed from the perspective of kill chain construction. Finally, the simulation of a typical network information system is carried out. The experimental results show that the proposed method can not only measure the agile construction ability of kill chains effectively, but also can provide feedback and guidance for optimization design of architecture of network information system.