Abstract: To enhance air combat effectiveness, this study investigates the intelligent cooperative combat mode of manned-unmanned aerial vehicles（UAVs）in complex battlefield environments under the guidance of Mosaic Warfare. The current research status of mannedunmanned aerial vehicle cooperative combat is reviewed, and the characteristics of traditional cooperative formations are analyzed. Building on this foundation, the concept of Mosaic Warfare is introduced, and an intelligent cooperative combat model for mannedunmanned aerial vehicles is designed. The feasibility of the proposed model is analyzed, and its cooperative mechanisms are described in detail. The operational advantages of the model are evaluated in terms of flexibility, decision-making capability, survivability, war costs, lethality, and security. Finally, the key technologies required for implementing this intelligent cooperative combat mode are summarized from six perspectives.